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Pfizer Inc. (PFE), Novartis AG and AstraZeneca PLC (AZN) Cancer Drugs Aromasin, Arimidex, and Lacoste Jumpers

AstraZeneca PLC Takes 445 Million Charge on Failure Polo Shirt Suppliers Philippines of MedImmune RSV Therapy

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Motavizumab is an investigational monoclonal antibody that was being considered to help prevent RSV disease. MedImmune filed the original BLA on 30 January 2008, and received its first complete response letter (CRL) in November 2008. Motavizumab was reviewed by the FDA's Antiviral Drugs Advisory Committee on 2 June 2010, and the Plain Polo Shirts Wholesale Philippines

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As a result of this decision, AstraZeneca will incur a financial impairment charge of $445 million in the fourth quarter 2010 accounts. As previously disclosed, the Group holds intangible assets of $445 million relating specifically to motavizumab. Consistent with previous disclosures, the impairment will be excluded from Core earnings, and thus has no impact on the Company's guidance for Core earnings per share for 2010.

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AstraZeneca today announced it has discontinued further development of motavizumab for the prophylaxis of serious respiratory syncytial virus (RSV) disease. The Company has requested withdrawal of the Biological License Application (BLA) pending at the US Food and Drug Administration (FDA).

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FDA issued a second CRL requesting additional clinical data in August 2010. Subsequently MedImmune has decided to discontinue certain motavizumab development paths and withdraw the prophylaxis BLA from the FDA; however, motavizumab remains in development for other RSV treatment.

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